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Gap19 TFA (1507930-57-5 free base)

CAS No.

Gap19 TFA (1507930-57-5 free base) ( )

Catalog No. M30210 CAS No.

Gap19 TFA is a peptide derived from nine amino acids of Cx43 cytoplasmic ring (CL), an effective, selective connexin 43 (Cx43) half-channel blocker.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Gap19 TFA (1507930-57-5 free base)
  • Note
    Research use only, not for human use.
  • Brief Description
    Gap19 TFA is a peptide derived from nine amino acids of Cx43 cytoplasmic ring (CL), an effective, selective connexin 43 (Cx43) half-channel blocker.
  • Description
    Gap19 TFA is a peptide derived from nine amino acids of Cx43 cytoplasmic ring (CL), an effective, selective connexin 43 (Cx43) half-channel blocker.(In Vitro):Gap19 TFA (250 μM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 TFA (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 TFA (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. Gap19 TFA (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo. (In Vivo):Gap19 TFA (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth.
  • Synonyms
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Cx43 Hemichannel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    --
  • Formula Weight
    1275.5
  • Molecular Formula
    C57H97F3N14O15
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Boengler K, et al. Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013 Jun 6;4:73.
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